Wednesday, March 29, 2023

AAP Updates Clinical Advice on Treating Children with Genetic Disorder, Neurofibromatosis Type 1

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A year-old boy presented for evaluation of his worsening behavior at school. He was very hyperactive and had difficulty in paying attention. He had always required help with reading and language. Maternal pregnancy and birth history were unremarkable. During the physical examination, the patient was noted to have 8 hyperpigmented macules ranging from 2 to 8 cm with smooth margins, 7 or 8 flesh-colored, nontender papules, and 3 nodules on the trunk A. His mother had numerous similar lesions on her trunk B. Neither son nor mother had any changes in vision, heart murmur, or bony deformity. A diagnosis of neurofibromatosis had been suspected by a previous physician but had not been confirmed. Neurofibromatosis type I, first described by von Recklinghausen in , is one of the most common autosomal dominant neurocutaneous conditions. The estimated incidence is 1 in to persons, independent of ethnicity, race, and gender. Formal diagnostic criteria were established by the Health Consensus Development Conference in Currently, the diagnosis is made when 2 or more of the following clinical features are present 2 :. All children with neurofibromatosis type I should have a developmental and neuropsychological assessment before school entry for educational planning.

UAB researchers work to unravel the complex genetic disease neurofibromatosis type 1

Usually this can mean late childhood, around age , or even not until adolescence. Puberty is a particularly common time for other features of NF1 to. Individuals who have not developed neurofibromas during childhood often begin to see skin neurofibromas during puberty. Pre-existing plexiform neurofibromas. Six or more café au lait macules larger than cm before puberty and cm after puberty. These hyperpigmented macules with smooth margins typically appear. Individuals with NF1 due to mutations in the NF1 gene may have macrocephaly but usually have short stature, often with delayed puberty and. of dermal neurofibromas coincide with puberty and severe proptosis, and/or hydrocephalus–20 Precocious puberty also can be an occasional complication.

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You need a wax. But what are the intricacies that go along with a wax? Believe it or not, there are plenty of dos and don ts after waxing and pre-appointment, too! So print this page out, hang it on your fridge, save it to your phone or share it with your friends via social media because this is your ultimate guide to all-things-waxing. For starters, say I do to waxing. There you go. Do remember to share with your wax specialists should you be allergic to any skin ointments, etc. Medications such as isotretinoin or tretinoin, aka retinoic acid, thin your skin , thereby potentially causing it to tear upon waxing. Do embrace your body. This is a judgment-free zone. Do your due diligence: Always, always go to a clean wax salon that upholds sanitary practices. We, of course, recommend Waxxpot! Do grow your hair out to the correct length.

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A premium, all-purpose, NLGI 2, extreme pressure, lithium complex bicycle grease. Pedro's Grease is excellent for bearing applications, assembly tasks, threads, and component interfaces. Formulated to have an excellent dropping point, superior water resistance, and outstanding structural stability over a wide range of temperatures, Pedro's Grease is the grease of choice for those that demand the best. Pedro's Grease Data Sheet. Home Pedro's Grease. Pedro's Grease. Add to Cart. US shipping only. Low friction, long service life, superior corrosion protection, and anti-wear protection. Excellent for most bicycle applications including bearings. Pedro's Grease Data Sheet Usage Clean or degrease component as needed prior to application of grease. Apply light coating of grease to component surfaces and wipe all excess. Pedro's Grease is recommended for all bicycle applications including wheels and bearings. New to bike care? Start here.

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What grease should I use on my bike and why?

Headset bearings see a lot of lateral force under braking, and they can shift even with the tightest of tolerances. The bearing rings should, of course, get grease, but the wedge-shaped ring below the top cap is the heart of the headset and often the cause of creaking. Keeping it sloppy will keep your headset tight. Thru axles get threaded and unthreaded more often than any other part on our bike. Some grease and care may eventually save you from a really bad day. By signing up you agree to our Terms and Conditions and Privacy Policy. Thank you for signing up. Your information has been successfully processed! Travis Engel Photo: Anthony Smith 2 years ago. Videos Hacks From Home: Vol. Travis Engel 3 years ago.

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Grease Testing and Frequently Asked Questions. With proper care and lubrication, S and S Couplings should outlast your frame! The only drawback is that it is expensive. I frequently get e-mail from people telling me that they want to use another type of grease commonly found in bike shops or automotive parts stores. We have listed all the products that we've tested below in the tables in the order of how well they performed with the best products at the top. If you look closely at the results in the tables below, you will see that some products actually perform worse than no lubricant at all. DTBG was discontinued as a bicycle grease several years ago. When we found out that it was being discontinued, we stocked up on it so we would have a temporary supply for our customers. Although they may not stock it, any framebuilder on the list or you can order it direct from us. We have included our testing method here because it's the best way we know of to convince our customers that not all grease is the same. He responded by rolling his eyes back in disbelief saying "come on, grease is grease". That wasn't the first time I had heard a comment like that so I invited him to come to my booth for a demonstration so he could see for himself how different grease can be. He accepted my offer so for starters, I set up the portable grease testing device and had him pick from a variety of popular greases that I had with me he picked white lithium grease. I applied the grease to the screw and placed the screw and nut in the tester to the point that it was ready to begin the test. I had him turn the wrench.

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Four (Includes Sheila E. Drum Solo) [Live In Utrecht - 2020 Remaster]

Listen to Drum Solo / Intro / Santana Medley on Spotify. Prince · Song · He was a miracle musician. Great songwriter and singer - and producer - but exceptional on so many instruments. His solo here is all soul - he is crying pure. Jun 29, - from the archives of Andreas Luescher - Swiss TV copyright free:Sheila E.:Before she became a solo artist in , drummer Sheila E. played. Sheila Cecilia Escovedo (born December 12, ) better known under the stage name Sheila E., is an American percussionist and singer. She began her career. Listen to Raw Beats (Drum Solo) [feat. Prince Thornton] by Sean Wright, 60 Shazams.

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The drum solo is that one showstopping moment during a concert that allows the drummer to shake the restrictive chains of timekeeper and showcase their flamboyant and bombastic skills. It's come a long way since the jazz days when Buddy Rich was king of the hill — drummers' kits are a lot bigger and Prince Drum Solo skills have advanced to levels that would have seemed inhuman 60 years ago — and the drum solo's appeal Prince Drum Solo only grown. Unlike Prince Drum Solo ranking of the best guitar solos of all time, which were exclusively studio recordings, we decided to only include live Prince Drum Solo solos in this list. Whereas guitar solos are often mainstays of a song, studio recordings usually only feature drum fills, which offer only a few seconds of percussive showmanship. The energy and improvisation of the drum solo are often best experienced live. Though his drum solo from Santana's Woodstock performance of "Soul Sacrifice" is highly revered, Michael Shrieve's solo during the band's performance of the song a year later at Tanglewood is even more mindblowing. What's so fun about this solo is how it starts on the congas, not the drum set. Shrieve lays low and lets the percussion section Prince Drum Solo the tempo and groove. Then, in an instant, it all comes burning down as Shrieve crashes and starts rolling on the snare. Shrieve's energy and dexterity are admirable during this solo, and he absolutely goes to town rolling between the snare drum and his two toms.

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A new retail-tracking technology for shops could mean an end to queueing, clever real-time discounts and even shopping-list help. Sometimes the biggest changes in technology have the smallest beginnings. In the summer of , Apple announced iBeacon, a nerdy-sounding feature of its new operating system that would "provide apps a whole new level of location awareness". It's taken a few months to appear in the real world, but from CES to grocery stores — and, of course, Apple's shops themselves — iBeacon now seems to be popping up everywhere. It's a new technology developed by Apple, built into its operating systems and devices since , and it may " change the world forever ", according to the Washington Post. The technology lets businesses set up transmitters which can tell nearby smartphones of their presence. It may not sound like much, but combined with the right software, it opens up a massive number of possibilities. With iBeacon set up, shops could send customers special offers for goods they are walking past, prepare pre-ordered items for pickup the minute someone comes through the door the end of queueing! And it can be used in more than just retail. Nomi , a New York-based firm which specialises in these sort of set-ups, has worked with theme parks, concert venues and stadiums, as well as restaurants and car companies. While iBeacon brings the advantages of the internet to the real world, it also brings the downsides. Just using data from old-fashioned loyalty cards, the US retailer Target famously discovered a teenage girl was pregnant before her own father knew ; think how much more information can be inferred by knowing not only what a customer has bought, but also how long they stopped to look at a product they didn't buy, how hurriedly they moved through the store, and the times they didn't buy anything at all. But for iBeacon to work, customers need to install the app of the retailer they are visiting, providing an easy way to opt out of any tracking.

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We have already told you about them back in , when they were only starting their conquest of Swiss nightlife scene with their iBeacon-enabled dating app. Article #: ; Date of Conference: March ; Date Added to IEEE Xplore: 23 April Considering that iBeacons are basically triggers for functionality, it makes sense that some of this functionality might be to bring the app into the foreground. Although Apple only released the specification for BLE devices to broadcast iBeacon signals at the end of , they'd been cleverly putting Bluetooth 1. Terminology confusion: Beacon is a Bluetooth low energy device. iBeacon is the technology developed by Apple for its iOS platform. Likewise.

Apr 9, - A startup called Mingleton is introducing a new mobile dating application that uses iBeacon technology to help you connect only with people. Live Beacon is a small, battery-powered, cloud-controlled device that Beacons + Cloud Portal + Free App “The simplest iBeacon device out there.”. Advertising Beacon Device. Bluetooth Low Energy®. Full Eddystone & iBeacon compatible. % Configurable Parameters. Firmware update Over The Air (OTA). The shopBeacon program involves the integration of iBeacon's technology with the Shopkick app. iBeacon's mobile-location based devices are. Date received: 4 June ; accepted: 11 December Handling Editor: Zenghua Zhao iBeacon devices that can give accurate position estimate.

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Busting Myths About Red Meat

Eating red and processed meat, the headlines declared, was no longer unhealthy. It seemed—at a glance—that a bad thing was now a good thing. “There's evidence that shows red meat and processed meats – such as bacon and sausage – are not good for your health,” says Zumpano. Daily consumption of red meat is bad for your health, as it increases your risk of heart disease, diabetes, and cancer. However, that doesn't. Another study, conducted by the National Institutes of Health titled the “AARP Diet and Health Study”, did find a correlation of meat, heart. Meat is a good source of various nutrients. Beef, pork, and lamb, contain vitamins A, B, D, and K, as well as copper, chromium, folic acid.

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New Research Has Major Outlets Claiming That Red Meat Is Good For You – We Took A Closer Look

Eating meat can be part of a balanced diet. "When lean meats are consumed in a proper balance with fruits, vegetables and whole grains, it can. Experts say eating meat every day isn't necessarily a bad thing — as long as you choose the right types. Image Credit: Most notably, meat is high in B vitamins, and zinc and particularly red meat is a good source of well absorbed iron (heme iron). Meat: Good or Bad? Meat is a highly controversial food. On one hand, it's a staple in many diets and a great source of protein and important. So the next time anyone will ask 'Is meat good or bad for health?” You know what to tell them. Meat can provide you with the required energy. The study found that eating red meat or processed meats doesn't increase our risk of heart disease, cancer or other chronic health conditions. “Cooking red meat at high temperatures may also increase cancer risk, and red meats tend to be higher in saturated fats than other protein.